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HomeFocus → New Study IDs Molecular Aging 'Midlife' Crisis

New Study IDs Molecular Aging 'Midlife' Crisis Print E-mail
Written by University of Miami Miller School of Medicine   
Monday, 10 June 2019 00:00

Just as a computer requires code to work, our bodies are regulated by molecular "programs" that are written early in life and then have to do their job properly for a lifetime. But do they? It's a question that has intrigued researchers for years.
 
Claes Wahlestedt, MD, PhD, professor of psychiatry and behavioral sciences and associate dean for therapeutic innovation at the University of Miami Miller School of Medicine, is senior author of a new study - "Longevity Related Molecular Pathways Are Subject to Midlife 'Switch' in Humans" - published June 6 in Aging Cell.

Working with first author Jamie Timmons, PhD, of King's College London and Stirling University Science Park, United Kingdom, and an international group of researchers on human aging, Dr. Wahlestedt made a striking observation: Key molecular programs known to promote longevity do not last beyond midlife.
 
The study provides a possible new reason why the human disease burden increases so sharply from the sixth decade of life onward as health-protective mechanisms disappear. Which raises the question: If one wishes to boost these established "anti-aging" programs with drugs, nutrients, or lifestyle choices, is it too late to start by the time you reach your 60s? Possibly, said Dr. Wahlestedt - at least if you hope to benefit fully from such interventions.

Last Updated on Tuesday, 11 June 2019 12:15
 


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